Combination of a Selective HSP90α/β Inhibitor and a RAS-RAF-MEK-ERK Signaling Pathway Inhibitor Trig...
Combination of a Selective HSP90α/β Inhibitor and a RAS-RAF-MEK-ERK Signaling Pathway Inhibitor Triggers Synergistic Cytotoxicity in Multiple Myeloma Cells
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Author / Creator
Suzuki, Rikio , Kikuchi, Shohei , Harada, Takeshi , Mimura, Naoya , Minami, Jiro , Ohguchi, Hiroto , Yoshida, Yasuhiro , Sagawa, Morihiko , Gorgun, Gullu , Cirstea, Diana , Cottini, Francesca , Jakubikova, Jana , Tai, Yu-Tzu , Chauhan, Dharminder , Richardson, Paul G. , Munshi, Nikhil , Ando, Kiyoshi , Utsugi, Teruhiro , Hideshima, Teru and Anderson, Kenneth C.
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Heat shock protein (HSP)90 inhibitors have shown significant anti-tumor activities in preclinical settings in both solid and hematological tumors. We previously reported that the novel, orally available HSP90α/β inhibitor TAS-116 shows significant anti-MM activities. In this study, we further examined the combination effect of TAS-116 with a RAS-RA...
Alternative Titles
Full title
Combination of a Selective HSP90α/β Inhibitor and a RAS-RAF-MEK-ERK Signaling Pathway Inhibitor Triggers Synergistic Cytotoxicity in Multiple Myeloma Cells
Authors, Artists and Contributors
Author / Creator
Kikuchi, Shohei
Harada, Takeshi
Mimura, Naoya
Minami, Jiro
Ohguchi, Hiroto
Yoshida, Yasuhiro
Sagawa, Morihiko
Gorgun, Gullu
Cirstea, Diana
Cottini, Francesca
Jakubikova, Jana
Tai, Yu-Tzu
Chauhan, Dharminder
Richardson, Paul G.
Munshi, Nikhil
Ando, Kiyoshi
Utsugi, Teruhiro
Hideshima, Teru
Anderson, Kenneth C.
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Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1738753592
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1738753592
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0143847
