Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associa...
Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic tumor with a dismal prognosis for most patients. Fibrosis and inflammation are hallmarks of tumor desmoplasia. We have previously demonstrated that preventing the activation of pancreatic stellate cells (PSCs) and alleviating desmoplasia are beneficial strategies in treating PDAC. Met...
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Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages
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TN_cdi_plos_journals_1746586601
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1746586601
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0141392
