The Fanconi Anemia Pathway Protects Genome Integrity from R-loops
The Fanconi Anemia Pathway Protects Genome Integrity from R-loops
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Co-transcriptional RNA-DNA hybrids (R loops) cause genome instability. To prevent harmful R loop accumulation, cells have evolved specific eukaryotic factors, one being the BRCA2 double-strand break repair protein. As BRCA2 also protects stalled replication forks and is the FANCD1 member of the Fanconi Anemia (FA) pathway, we investigated the FA ro...
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Full title
The Fanconi Anemia Pathway Protects Genome Integrity from R-loops
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TN_cdi_plos_journals_1749629264
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1749629264
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1005674
