Evolution of Robustness to Protein Mistranslation by Accelerated Protein Turnover
Evolution of Robustness to Protein Mistranslation by Accelerated Protein Turnover
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Translational errors occur at high rates, and they influence organism viability and the onset of genetic diseases. To investigate how organisms mitigate the deleterious effects of protein synthesis errors during evolution, a mutant yeast strain was engineered to translate a codon ambiguously (mistranslation). It thereby overloads the protein qualit...
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Full title
Evolution of Robustness to Protein Mistranslation by Accelerated Protein Turnover
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TN_cdi_plos_journals_1749631474
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1749631474
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ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.1002291
