γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavag...
γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP)
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Contents
The relative increase in Aβ42 peptides from familial Alzheimer disease (FAD) linked APP and PSEN mutations can be related to changes in both ε-cleavage site utilization and subsequent step-wise cleavage. Cleavage at the ε-site releases the amyloid precursor protein (APP) intracellular domain (AICD), and perturbations in the position of ε-cleavage a...
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Full title
γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP)
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TN_cdi_plos_journals_1749962139
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1749962139
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0144758
