Engineering FKBP-Based Destabilizing Domains to Build Sophisticated Protein Regulation Systems
Engineering FKBP-Based Destabilizing Domains to Build Sophisticated Protein Regulation Systems
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Targeting protein stability with small molecules has emerged as an effective tool to control protein abundance in a fast, scalable and reversible manner. The technique involves tagging a protein of interest (POI) with a destabilizing domain (DD) specifically controlled by a small molecule. The successful construction of such fusion proteins may, ho...
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Full title
Engineering FKBP-Based Destabilizing Domains to Build Sophisticated Protein Regulation Systems
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TN_cdi_plos_journals_1752582940
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1752582940
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0145783
