Using Human iPSC-Derived Neurons to Model TAU Aggregation
Using Human iPSC-Derived Neurons to Model TAU Aggregation
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Alzheimer's disease and frontotemporal dementia are amongst the most common forms of dementia characterized by the formation and deposition of abnormal TAU in the brain. In order to develop a translational human TAU aggregation model suitable for screening, we transduced TAU harboring the pro-aggregating P301L mutation into control hiPSC-derived ne...
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Full title
Using Human iPSC-Derived Neurons to Model TAU Aggregation
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TN_cdi_plos_journals_1752786338
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1752786338
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0146127
