Rapamycin Attenuates Splenomegaly in both Intrahepatic and Prehepatic Portal Hypertensive Rats by Bl...
Rapamycin Attenuates Splenomegaly in both Intrahepatic and Prehepatic Portal Hypertensive Rats by Blocking mTOR Signaling Pathway
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Author / Creator
Chen, Yunyang , Wang, Weijie , Wang, Huakai , Li, Yongjian , Shi, Minmin , Li, Hongwei and Yan, Jiqi
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Spleen enlargement is often detected in patients with liver cirrhosis, but the precise pathogenetic mechanisms behind the phenomenon have not been clearly elucidated. We investigated the pathogenetic mechanisms of splenomegaly in both portal hypertensive patients and rats, and tried to identify the possible therapy for this disease.
Spleen sampl...
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Full title
Rapamycin Attenuates Splenomegaly in both Intrahepatic and Prehepatic Portal Hypertensive Rats by Blocking mTOR Signaling Pathway
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TN_cdi_plos_journals_1754026687
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1754026687
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0141159
