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Heat Shock Protein 27 Plays a Pivotal Role in Myofibroblast Differentiation and in the Development o...

Heat Shock Protein 27 Plays a Pivotal Role in Myofibroblast Differentiation and in the Development o...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1764135271

Heat Shock Protein 27 Plays a Pivotal Role in Myofibroblast Differentiation and in the Development of Bleomycin-Induced Pulmonary Fibrosis

About this item

Full title

Heat Shock Protein 27 Plays a Pivotal Role in Myofibroblast Differentiation and in the Development of Bleomycin-Induced Pulmonary Fibrosis

Publisher

United States: Public Library of Science

Journal title

PloS one, 2016-02, Vol.11 (2), p.e0148998-e0148998

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Heat shock protein 27 (HSP27) is a member of the small molecular weight HSP family. Upon treatment with transforming growth factor β1 (TGF-β1), we observed upregulation of HSP27 along with that of α-smooth muscle actin (α-SMA), a marker of myofibroblast differentiation, in cultured human and mouse lung fibroblasts. Furthermore, by using siRNA knock...

Alternative Titles

Full title

Heat Shock Protein 27 Plays a Pivotal Role in Myofibroblast Differentiation and in the Development of Bleomycin-Induced Pulmonary Fibrosis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1764135271

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1764135271

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0148998

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