Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Cateni...
Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin Puncta
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Activation of the wnt signaling pathway is a major cause of colon cancer development. Tankyrase inhibitors (TNKSi) have recently been developed to block the wnt pathway by increasing axin levels to promote degradation of the wnt-regulator β-catenin. TNKSi bind to the PARP (poly(ADP)ribose polymerase) catalytic region of tankyrases (TNKS), preventin...
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Full title
Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin Puncta
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TN_cdi_plos_journals_1769623161
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1769623161
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0150484
