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Human [Beta]-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic...

Human [Beta]-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1774175646

Human [Beta]-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid

About this item

Full title

Human [Beta]-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid

Publisher

Public Library of Science

Journal title

PLoS genetics, 2015-12, Vol.11 (12)

Language

English

Formats

Publication information

Publisher

Public Library of Science

More information

Scope and Contents

Contents

 
Human [Beta]-defensin 3 (hBD3) is a cationic host defence peptide and is part of the innate immune response. HBD3 is present on a highly copy number variable block of six [Beta]-defensin genes, and increased copy number is associated with the autoimmune disease psoriasis. It is not known how this increase influences disease development, but ps...

Alternative Titles

Full title

Human [Beta]-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1774175646

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1774175646

Other Identifiers

E-ISSN

1553-7404

DOI

10.1371/journal.pgen.1005673

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