MTH1 Substrate Recognition—An Example of Specific Promiscuity
MTH1 Substrate Recognition—An Example of Specific Promiscuity
About this item
Full title
Author / Creator
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
MTH1 (NUDT1) is an oncologic target involved in the prevention of DNA damage. We investigate the way MTH1 recognises its substrates and present substrate-bound structures of MTH1 for 8-oxo-dGTP and 8-oxo-rATP as examples of novel strong and weak binding substrate motifs. Investigation of a small set of purine-like fragments using 2D NMR resulted in...
Alternative Titles
Full title
MTH1 Substrate Recognition—An Example of Specific Promiscuity
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1774764232
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1774764232
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0151154
