Acetylation of Lysine 201 Inhibits the DNA-Binding Ability of PhoP to Regulate Salmonella Virulence
Acetylation of Lysine 201 Inhibits the DNA-Binding Ability of PhoP to Regulate Salmonella Virulence
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Author / Creator
Ren, Jie , Sang, Yu , Tan, Yongcong , Tao, Jing , Ni, Jinjing , Liu, Shuting , Fan, Xia , Zhao, Wei , Lu, Jie , Wu, Wenjuan and Yao, Yu-Feng
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Contents
The two-component system PhoP-PhoQ is highly conserved in bacteria and regulates virulence in response to various signals for bacteria within the mammalian host. Here, we demonstrate that PhoP could be acetylated by Pat and deacetylated by deacetylase CobB enzymatically in vitro and in vivo in Salmonella Typhimurium. Specifically, the conserved lys...
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Full title
Acetylation of Lysine 201 Inhibits the DNA-Binding Ability of PhoP to Regulate Salmonella Virulence
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TN_cdi_plos_journals_1777281089
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1777281089
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1005458
