Enhancing Beta-Catenin Activity via GSK3beta Inhibition Protects PC12 Cells against Rotenone Toxicit...
Enhancing Beta-Catenin Activity via GSK3beta Inhibition Protects PC12 Cells against Rotenone Toxicity through Nurr1 Induction
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Author / Creator
Zhang, Limin , Cen, Luan , Qu, Shaogang , Wei, Lei , Mo, Mingshu , Feng, Junmin , Sun, Congcong , Xiao, Yousheng , Luo, Qin , Li, Shaomin , Yang, Xinling and Xu, Pingyi
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Contents
Parkinson's disease (PD) is characterized by progressive degeneration of dopaminergic (DA) neurons in the substantial nigra pars compacta. Increasing evidence showed that Wnt/β-catenin pathway and the orphan nuclear receptor Nurr1 play crucial roles in the survival and functional maintenance of DA neurons in the midbrain and GSK-3β antagonists LiCl...
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Full title
Enhancing Beta-Catenin Activity via GSK3beta Inhibition Protects PC12 Cells against Rotenone Toxicity through Nurr1 Induction
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TN_cdi_plos_journals_1778767622
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1778767622
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0152931
