Transgenic Expression of Human Lysophosphatidic Acid Receptor LPA2 in Mouse Intestinal Epithelial Ce...
Transgenic Expression of Human Lysophosphatidic Acid Receptor LPA2 in Mouse Intestinal Epithelial Cells Induces Intestinal Dysplasia
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Lysophosphatidic acid (LPA) acts on LPA2 receptor to mediate multiple pathological effects that are associated with tumorigenesis. The absence of LPA2 attenuates tumor progression in rodent models of colorectal cancer, but whether overexpression of LPA2 alone can lead to malignant transformation in the intestinal tract has not been studied. In this...
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Transgenic Expression of Human Lysophosphatidic Acid Receptor LPA2 in Mouse Intestinal Epithelial Cells Induces Intestinal Dysplasia
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TN_cdi_plos_journals_1785219934
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1785219934
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0154527
