MEK Inhibition Sensitizes Precursor B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells to Dexamethaso...
MEK Inhibition Sensitizes Precursor B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells to Dexamethasone through Modulation of mTOR Activity and Stimulation of Autophagy
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Author / Creator
Polak, Anna , Kiliszek, Przemysław , Sewastianik, Tomasz , Szydłowski, Maciej , Jabłońska, Ewa , Białopiotrowicz, Emilia , Górniak, Patryk , Markowicz, Sergiusz , Nowak, Eliza , Grygorowicz, Monika A. , Prochorec-Sobieszek, Monika , Nowis, Dominika , Gołąb, Jakub , Giebel, Sebastian , Lech-Marańda, Ewa , Warzocha, Krzysztof and Juszczyński, Przemysław
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Resistance to glucocorticosteroids (GCs) is a major adverse prognostic factor in B-ALL, but the molecular mechanisms leading to GC resistance are not completely understood. Herein, we sought to elucidate the molecular background of GC resistance in B-ALL and characterize the therapeutic potential of targeted intervention in these mechanisms. Using...
Alternative Titles
Full title
MEK Inhibition Sensitizes Precursor B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells to Dexamethasone through Modulation of mTOR Activity and Stimulation of Autophagy
Authors, Artists and Contributors
Author / Creator
Kiliszek, Przemysław
Sewastianik, Tomasz
Szydłowski, Maciej
Jabłońska, Ewa
Białopiotrowicz, Emilia
Górniak, Patryk
Markowicz, Sergiusz
Nowak, Eliza
Grygorowicz, Monika A.
Prochorec-Sobieszek, Monika
Nowis, Dominika
Gołąb, Jakub
Giebel, Sebastian
Lech-Marańda, Ewa
Warzocha, Krzysztof
Juszczyński, Przemysław
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1790065547
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1790065547
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0155893
