Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Indepen...
Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Topoisomerase 1 (TOP1) inhibitors, including camptothecin and topotecan, covalently trap TOP1 on DNA, creating cleavage complexes (cc's) that must be resolved before gene transcription and DNA replication can proceed. We previously found that topotecan reduces the expression of long (>100 kb) genes and unsilences the paternal allele of Ube3a in neu...
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Full title
Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms
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TN_cdi_plos_journals_1792179318
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1792179318
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0156439
