Functional Sites Induce Long-Range Evolutionary Constraints in Enzymes
Functional Sites Induce Long-Range Evolutionary Constraints in Enzymes
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Functional residues in proteins tend to be highly conserved over evolutionary time. However, to what extent functional sites impose evolutionary constraints on nearby or even more distant residues is not known. Here, we report pervasive conservation gradients toward catalytic residues in a dataset of 524 distinct enzymes: evolutionary conservation...
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Functional Sites Induce Long-Range Evolutionary Constraints in Enzymes
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TN_cdi_plos_journals_1797504287
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1797504287
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ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.1002452
