Neprilysin Inhibits Coagulation through Proteolytic Inactivation of Fibrinogen
Neprilysin Inhibits Coagulation through Proteolytic Inactivation of Fibrinogen
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Neprilysin (NEP) is an endogenous protease that degrades a wide range of peptides including amyloid beta (Aβ), the main pathological component of Alzheimer's disease (AD). We have engineered NEP as a potential therapeutic for AD but found in pre-clinical safety testing that this variant increased prothrombin time (PT) and activated partial thrombop...
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Neprilysin Inhibits Coagulation through Proteolytic Inactivation of Fibrinogen
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TN_cdi_plos_journals_1805757219
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1805757219
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0158114
