Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics
Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics
About this item
Full title
Author / Creator
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
The auristatin class of microtubule destabilizers are highly potent cytotoxic agents against several cancer cell types when delivered as antibody drug conjugates. Here we describe the high resolution structures of tubulin in complex with both monomethyl auristatin E and F and unambiguously define the trans-configuration of both ligands at the Val-D...
Alternative Titles
Full title
Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1812541341
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1812541341
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0160890
