COMT Val158Met Polymorphism Modulates Huntington's Disease Progression
COMT Val158Met Polymorphism Modulates Huntington's Disease Progression
About this item
Full title
Author / Creator
de Diego-Balaguer, Ruth , Schramm, Catherine , Rebeix, Isabelle , Dupoux, Emmanuel , Durr, Alexandra , Brice, Alexis , Charles, Perrine , Cleret de Langavant, Laurent , Youssov, Katia , Verny, Christophe , Damotte, Vincent , Azulay, Jean-Philippe , Goizet, Cyril , Simonin, Clémence , Tranchant, Christine , Maison, Patrick , Rialland, Amandine , Schmitz, David , Jacquemot, Charlotte , Fontaine, Bertrand , Bachoud-Lévi, Anne-Catherine , the French Speaking Huntington Group and French Speaking Huntington Group
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
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More information
Scope and Contents
Contents
Little is known about the genetic factors modulating the progression of Huntington's disease (HD). Dopamine levels are affected in HD and modulate executive functions, the main cognitive disorder of HD. We investigated whether the Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene, which influences dopamine (DA) degradation, aff...
Alternative Titles
Full title
COMT Val158Met Polymorphism Modulates Huntington's Disease Progression
Authors, Artists and Contributors
Author / Creator
Schramm, Catherine
Rebeix, Isabelle
Dupoux, Emmanuel
Durr, Alexandra
Brice, Alexis
Charles, Perrine
Cleret de Langavant, Laurent
Youssov, Katia
Verny, Christophe
Damotte, Vincent
Azulay, Jean-Philippe
Goizet, Cyril
Simonin, Clémence
Tranchant, Christine
Maison, Patrick
Rialland, Amandine
Schmitz, David
Jacquemot, Charlotte
Fontaine, Bertrand
Bachoud-Lévi, Anne-Catherine
the French Speaking Huntington Group
French Speaking Huntington Group
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1822391509
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1822391509
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0161106
