A Positive Selection for Nucleoside Kinases in E. coli
A Positive Selection for Nucleoside Kinases in E. coli
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Engineering heterologous nucleoside kinases inside E. coli is a difficult process due to the integral role nucleosides play in cell division and transcription. Nucleoside analogs are used in many kinase screens that depend on cellular metabolization of the analogs. However, metabolic activation of these analogs can be toxic through disruptions of D...
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Full title
A Positive Selection for Nucleoside Kinases in E. coli
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TN_cdi_plos_journals_1825255931
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1825255931
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0162921
