Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Cau...
Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly
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United States: Public Library of Science
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English
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United States: Public Library of Science
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The exon junction complex (EJC) is an RNA binding complex comprised of the core components Magoh, Rbm8a, and Eif4a3. Human mutations in EJC components cause neurodevelopmental pathologies. Further, mice heterozygous for either Magoh or Rbm8a exhibit aberrant neurogenesis and microcephaly. Yet despite the requirement of these genes for neurodevelopm...
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Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly
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TN_cdi_plos_journals_1829443702
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1829443702
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1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1006282
