Model Linking Plasma and Intracellular Tenofovir/Emtricitabine with Deoxynucleoside Triphosphates
Model Linking Plasma and Intracellular Tenofovir/Emtricitabine with Deoxynucleoside Triphosphates
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Publisher
United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
The coformulation of the nucleos(t)ide analogs (NA) tenofovir (TFV) disoproxil fumarate (TDF) and emtricitabine (FTC) is approved for HIV-infection treatment and prevention. Plasma TFV and FTC undergo complicated hybrid processes to form, accumulate, and retain as their active intracellular anabolites: TFV-diphosphate (TFV-DP) and FTC-triphosphate...
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Full title
Model Linking Plasma and Intracellular Tenofovir/Emtricitabine with Deoxynucleoside Triphosphates
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TN_cdi_plos_journals_1838212075
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1838212075
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0165505
