Family Based Whole Exome Sequencing Reveals the Multifaceted Role of Notch Signaling in Congenital H...
Family Based Whole Exome Sequencing Reveals the Multifaceted Role of Notch Signaling in Congenital Heart Disease
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Left-ventricular outflow tract obstructions (LVOTO) encompass a wide spectrum of phenotypically heterogeneous heart malformations which frequently cluster in families. We performed family based whole-exome and targeted re-sequencing on 182 individuals from 51 families with multiple affected members. Central to our approach is the family unit which...
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Family Based Whole Exome Sequencing Reveals the Multifaceted Role of Notch Signaling in Congenital Heart Disease
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TN_cdi_plos_journals_1840944134
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1840944134
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1006335
