Inhibition of Notch Signaling Attenuates Schistosomiasis Hepatic Fibrosis via Blocking Macrophage M2...
Inhibition of Notch Signaling Attenuates Schistosomiasis Hepatic Fibrosis via Blocking Macrophage M2 Polarization
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Macrophages play a key role in the pathogenesis of liver granuloma and fibrosis in schistosomiasis. However, the underlying mechanisms have not been fully characterized. This study revealed that the macrophages infiltrating the liver tissues in a murine model of Schistosoma japonica infection exhibited M2 functional polarization, and Notch1/Jagged1...
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Full title
Inhibition of Notch Signaling Attenuates Schistosomiasis Hepatic Fibrosis via Blocking Macrophage M2 Polarization
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TN_cdi_plos_journals_1842507575
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1842507575
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0166808
