Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parki...
Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson’s Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Expression of Alpha Synuclein and Dopaminergic Degeneration in Macaque
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Recent failures in clinical trials for disease modification in Parkinson's disease have highlighted the need for a non-human primate model of the synucleinopathy underpinning dopaminergic neuron degeneration. The present study was defined to begin the development of such a model in cynomolgus macaque. We have validated surgical and vector parameter...
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Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson’s Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Expression of Alpha Synuclein and Dopaminergic Degeneration in Macaque
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TN_cdi_plos_journals_1844917263
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1844917263
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0167235
