Tamoxifen Isomers and Metabolites Exhibit Distinct Affinity and Activity at Cannabinoid Receptors: P...
Tamoxifen Isomers and Metabolites Exhibit Distinct Affinity and Activity at Cannabinoid Receptors: Potential Scaffold for Drug Development
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Tamoxifen (Tam) is a selective estrogen receptor (ER) modulator (SERM) that is an essential drug to treat ER-positive breast cancer. Aside from known actions at ERs, recent studies have suggested that some SERMs like Tam also exhibit novel activity at cannabinoid subtype 1 and 2 receptors (CB1R and CB2Rs). Interestingly, cis- (E-Tam) and trans- (Z-...
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Tamoxifen Isomers and Metabolites Exhibit Distinct Affinity and Activity at Cannabinoid Receptors: Potential Scaffold for Drug Development
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TN_cdi_plos_journals_1847563105
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1847563105
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0167240
