Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Vir...
Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
HIV-1 maturation inhibitors (MIs) disrupt the final step in the HIV-1 protease-mediated cleavage of the Gag polyprotein between capsid p24 capsid (CA) and spacer peptide 1 (SP1), leading to the production of infectious virus. BMS-955176 is a second generation MI with improved antiviral activity toward polymorphic Gag variants compared to a first ge...
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Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors
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TN_cdi_plos_journals_1849657007
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1849657007
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1005990
