Substrates and Inhibitors of SAMHD1
Substrates and Inhibitors of SAMHD1
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
SAMHD1 hydrolyzes 2'-deoxynucleoside-5'-triphosphates (dNTPs) into 2'-deoxynucleosides and inorganic triphosphate products. In this paper, we evaluated the impact of 2' sugar moiety substitution for different nucleotides on being substrates for SAMHD1 and mechanisms of actions for the results. We found that dNTPs ((2'R)-2'-H) are only permissive in...
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Full title
Substrates and Inhibitors of SAMHD1
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TN_cdi_plos_journals_1855069201
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1855069201
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0169052
