Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recogniti...
Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
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Author / Creator
Li, Ling , Zhang, Hailong , Zhang, Man , Zhao, Mengxi , Feng, Lijian , Luo, Xiao , Gao, Zhenting , Huang, Ying , Ardayfio, Ophelia , Zhang, Ji-Hu , Lin, Ying , Fan, Hong , Mi, Yuan , Li, Guobin , Liu, Lei , Feng, Leying , Luo, Fangjun , Teng, Lin , Qi, Wei , Ottl, Johannes , Lingel, Andreas , Bussiere, Dirksen E , Yu, Zhengtian , Atadja, Peter , Lu, Chris , Li, En , Gu, Justin and Zhao, Kehao
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Polycomb repressive complex 2 (PRC2), a histone H3 lysine 27 methyltransferase, plays a key role in gene regulation and is a known epigenetics drug target for cancer therapy. The WD40 domain-containing protein EED is the regulatory subunit of PRC2. It binds to the tri-methylated lysine 27 of the histone H3 (H3K27me3), and through which stimulates t...
Alternative Titles
Full title
Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
Authors, Artists and Contributors
Author / Creator
Zhang, Hailong
Zhang, Man
Zhao, Mengxi
Feng, Lijian
Luo, Xiao
Gao, Zhenting
Huang, Ying
Ardayfio, Ophelia
Zhang, Ji-Hu
Lin, Ying
Fan, Hong
Mi, Yuan
Li, Guobin
Liu, Lei
Feng, Leying
Luo, Fangjun
Teng, Lin
Qi, Wei
Ottl, Johannes
Lingel, Andreas
Bussiere, Dirksen E
Yu, Zhengtian
Atadja, Peter
Lu, Chris
Li, En
Gu, Justin
Zhao, Kehao
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1857360641
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1857360641
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0169855
