Resistance for Genotoxic Damage in Mesenchymal Stromal Cells Is Increased by Hypoxia but Not General...
Resistance for Genotoxic Damage in Mesenchymal Stromal Cells Is Increased by Hypoxia but Not Generally Dependent on p53-Regulated Cell Cycle Arrest
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Adult stem cells including multipotent mesenchymal stromal cells (MSC) acquire a high amount of DNA-damage due to their prolonged lifespan. MSC may exert specific mechanisms of resistance to avoid loss of functional activity. We have previously shown that resistance of MSC is associated with an induction of p53 and proliferation arrest upon genotox...
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Resistance for Genotoxic Damage in Mesenchymal Stromal Cells Is Increased by Hypoxia but Not Generally Dependent on p53-Regulated Cell Cycle Arrest
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TN_cdi_plos_journals_1858089272
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1858089272
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0169921
