Clonal Evolutionary Analysis during HER2 Blockade in HER2-Positive Inflammatory Breast Cancer: A Pha...
Clonal Evolutionary Analysis during HER2 Blockade in HER2-Positive Inflammatory Breast Cancer: A Phase II Open-Label Clinical Trial of Afatinib +/- Vinorelbine
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Author / Creator
Goh, Gerald , Schmid, Ramona , Guiver, Kelly , Arpornwirat, Wichit , Chitapanarux, Imjai , Ganju, Vinod , Im, Seock-Ah , Kim, Sung-Bae , Dechaphunkul, Arunee , Maneechavakajorn, Jedzada , Spector, Neil , Yau, Thomas , Afrit, Mehdi , Ahmed, Slim Ben , Johnston, Stephen R. , Gibson, Neil , Uttenreuther-Fischer, Martina , Herrero, Javier and Swanton, Charles
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Inflammatory breast cancer (IBC) is a rare, aggressive form of breast cancer associated with HER2 amplification, with high risk of metastasis and an estimated median survival of 2.9 y. We performed an open-label, single-arm phase II clinical trial (ClinicalTrials.gov NCT01325428) to investigate the efficacy and safety of afatinib, an irreversible E...
Alternative Titles
Full title
Clonal Evolutionary Analysis during HER2 Blockade in HER2-Positive Inflammatory Breast Cancer: A Phase II Open-Label Clinical Trial of Afatinib +/- Vinorelbine
Authors, Artists and Contributors
Author / Creator
Schmid, Ramona
Guiver, Kelly
Arpornwirat, Wichit
Chitapanarux, Imjai
Ganju, Vinod
Im, Seock-Ah
Kim, Sung-Bae
Dechaphunkul, Arunee
Maneechavakajorn, Jedzada
Spector, Neil
Yau, Thomas
Afrit, Mehdi
Ahmed, Slim Ben
Johnston, Stephen R.
Gibson, Neil
Uttenreuther-Fischer, Martina
Herrero, Javier
Swanton, Charles
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1858865555
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1858865555
Other Identifiers
ISSN
1549-1676,1549-1277
E-ISSN
1549-1676
DOI
10.1371/journal.pmed.1002136
