Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning...
Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment
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United States: Public Library of Science
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English
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United States: Public Library of Science
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In vertebrate neurons, the axon initial segment (AIS) is specialized for action potential initiation. It is organized by a giant 480 Kd variant of ankyrin G (AnkG) that serves as an anchor for ion channels and is required for a plasma membrane diffusion barrier that excludes somatodendritic proteins from the axon. An unusually long exon required to...
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Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment
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TN_cdi_plos_journals_1858865598
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1858865598
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1006457
