Radioiodinated Exendin-4 Is Superior to the Radiometal-Labelled Glucagon-Like Peptide-1 Receptor Pro...
Radioiodinated Exendin-4 Is Superior to the Radiometal-Labelled Glucagon-Like Peptide-1 Receptor Probes Overcoming Their High Kidney Uptake
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
GLP-1 receptors are ideal targets for preoperative imaging of benign insulinoma and for quantifying the beta cell mass. The existing clinical tracers targeting GLP-1R are all agonists with low specific activity and very high kidney uptake. In order to solve those issues we evaluated GLP-1R agonist Ex-4 and antagonist Ex(9-39) radioiodinated at Tyr4...
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Full title
Radioiodinated Exendin-4 Is Superior to the Radiometal-Labelled Glucagon-Like Peptide-1 Receptor Probes Overcoming Their High Kidney Uptake
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TN_cdi_plos_journals_1860107817
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1860107817
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0170435
