Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and β...
Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and β-Catenin Degradation
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Inhibition of the tankyrase enzymes (TNKS1 and TNKS2) has recently been shown to induce highly dynamic assemblies of β-catenin destruction complex components known as degradasomes, which promote degradation of β-catenin and reduced Wnt signaling activity in colorectal cancer cells. AXIN1 and AXIN2/Conductin, the rate-limiting factors for the stabil...
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Full title
Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and β-Catenin Degradation
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TN_cdi_plos_journals_1860295636
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1860295636
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0170508
