Engineered Aedes aegypti JAK/STAT Pathway-Mediated Immunity to Dengue Virus
Engineered Aedes aegypti JAK/STAT Pathway-Mediated Immunity to Dengue Virus
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
We have developed genetically modified Ae. aegypti mosquitoes that activate the conserved antiviral JAK/STAT pathway in the fat body tissue, by overexpressing either the receptor Dome or the Janus kinase Hop by the blood feeding-induced vitellogenin (Vg) promoter. Transgene expression inhibits infection with several dengue virus (DENV) serotypes in...
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Full title
Engineered Aedes aegypti JAK/STAT Pathway-Mediated Immunity to Dengue Virus
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TN_cdi_plos_journals_1869528421
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1869528421
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ISSN
1935-2735,1935-2727
E-ISSN
1935-2735
DOI
10.1371/journal.pntd.0005187
