Molecular mechanisms of cooperative binding of transcription factors Runx1-CBFβ-Ets1 on the TCRα gen...
Molecular mechanisms of cooperative binding of transcription factors Runx1-CBFβ-Ets1 on the TCRα gene enhancer
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Ets1 is an essential transcription factor (TF) for several important physiological processes, including cell proliferation and differentiation. Its recognition of the enhancer region of the TCRα gene is enhanced by the cooperative binding of the Runx1-CBFβ heterodimer, with the cancelation of phosphorylation-dependent autoinhibition. The detailed m...
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Full title
Molecular mechanisms of cooperative binding of transcription factors Runx1-CBFβ-Ets1 on the TCRα gene enhancer
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TN_cdi_plos_journals_1871525985
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1871525985
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0172654
