Formulation and PEGylation optimization of the therapeutic PEGylated phenylalanine ammonia lyase for...
Formulation and PEGylation optimization of the therapeutic PEGylated phenylalanine ammonia lyase for the treatment of phenylketonuria
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Phenylketonuria (PKU) is a genetic metabolic disease in which the decrease or loss of phenylalanine hydroxylase (PAH) activity results in elevated, neurotoxic levels of phenylalanine (Phe). Due to many obstacles, PAH enzyme replacement therapy is not currently an option. Treatment of PKU with an alternative enzyme, phenylalanine ammonia lyase (PAL)...
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Full title
Formulation and PEGylation optimization of the therapeutic PEGylated phenylalanine ammonia lyase for the treatment of phenylketonuria
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TN_cdi_plos_journals_1876058304
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1876058304
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0173269
