Hypoxia-inducible factor-2α stabilizes the von Hippel-Lindau (VHL) disease suppressor, Myb-related p...
Hypoxia-inducible factor-2α stabilizes the von Hippel-Lindau (VHL) disease suppressor, Myb-related protein 2
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Ubiquitin ligase von Hippel-Lindau tumor suppressor (pVHL) negatively regulates protein levels of hypoxia-inducible factor-α (HIF-α). Loss of pVHL causes HIF-α accumulation, which contributes to the pathogenesis of von Hippel-Lindau (VHL) disease. In contrast, v-Myb avian myeloblastosis viral oncogene homolog-like 2 (MYBL2; B-Myb), a transcription...
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Full title
Hypoxia-inducible factor-2α stabilizes the von Hippel-Lindau (VHL) disease suppressor, Myb-related protein 2
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TN_cdi_plos_journals_1886286772
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1886286772
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0175593
