Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.HttQ111/+ mou...
Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.HttQ111/+ mouse model of Huntington’s disease
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Author / Creator
Coffey, Sydney R. , Bragg, Robert M. , Minnig, Shawn , Ament, Seth A. , Cantle, Jeffrey P. , Glickenhaus, Anne , Shelnut, Daniel , Carrillo, José M. , Shuttleworth, Dominic D. , Rodier, Julie-Anne , Noguchi, Kimihiro , Bennett, C. Frank , Price, Nathan D. , Kordasiewicz, Holly B. and Carroll, Jeffrey B.
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease whose predominant neuropathological signature is the selective loss of medium spiny neurons in the striatum. Despite this selective neuropathology, the mutant protein (huntingtin) is found in virtually every cell so far studied, and, consequently, phenotypes are observed i...
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Full title
Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.HttQ111/+ mouse model of Huntington’s disease
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Record Identifier
TN_cdi_plos_journals_1892971843
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1892971843
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0175968
