The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer...
The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
CBP-93872 suppresses maintenance of DNA double-stranded break-induced G2 checkpoint, by inhibiting the pathway between ataxia-telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) activation. To examine the potential use of CBP-93872 for clinical applications, we analyzed the synergistic effects of platinum-containing drugs, oxaliplatin and...
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Full title
The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy
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TN_cdi_plos_journals_1903916163
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1903916163
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0178221
