Orexin receptor agonist Yan 7874 is a weak agonist of orexin/hypocretin receptors and shows orexin r...
Orexin receptor agonist Yan 7874 is a weak agonist of orexin/hypocretin receptors and shows orexin receptor-independent cytotoxicity
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Two promising lead structures of small molecular orexin receptor agonist have been reported, but without detailed analyses of the pharmacological properties. One of them, 1-(3,4-dichlorophenyl)-2-[2-imino-3-(4-methylbenzyl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl]ethan-1-ol (Yan 7874), is commercially available, and we set out to analyze its propertie...
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Orexin receptor agonist Yan 7874 is a weak agonist of orexin/hypocretin receptors and shows orexin receptor-independent cytotoxicity
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TN_cdi_plos_journals_1905486608
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1905486608
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1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0178526
