Loss of prion protein induces a primed state of type I interferon-responsive genes
Loss of prion protein induces a primed state of type I interferon-responsive genes
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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The cellular prion protein (PrPC) has been extensively studied because of its pivotal role in prion diseases; however, its functions remain incompletely understood. A unique line of goats has been identified that carries a nonsense mutation that abolishes synthesis of PrPC. In these animals, the PrP-encoding mRNA is rapidly degraded. Goats without...
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Full title
Loss of prion protein induces a primed state of type I interferon-responsive genes
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TN_cdi_plos_journals_1913783623
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1913783623
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0179881
