2,5-hexanedione downregulates nerve growth factor and induces neuron apoptosis in the spinal cord of...
2,5-hexanedione downregulates nerve growth factor and induces neuron apoptosis in the spinal cord of rats via inhibition of the PI3K/Akt signaling pathway
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Author / Creator
Wang, Zhemin , Qiu, Zewen , Gao, Chenxue , Sun, Yijie , Dong, Wei , Zhang, Yan , Chen, Ruolin , Qi, Yuan , Li, Shuangyue , Guo, Yanjie , Piao, Yongjun , Li, Sheng and Piao, Fengyuan
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
2,5-hexanedione (2,5-HD) is the main active metabolite of n-hexane and induces apoptosis in nerve tissue, however, the mechanism of which remains unclear. In the present study, neuropathic animal models were successfully constructed in rats by injecting 100, 200 and 400 mg/kg 2,5-HD intraperitoneally for 5 weeks. Rats exposed to 2,5-HD exhibited pr...
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Full title
2,5-hexanedione downregulates nerve growth factor and induces neuron apoptosis in the spinal cord of rats via inhibition of the PI3K/Akt signaling pathway
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TN_cdi_plos_journals_1914149063
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1914149063
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0179388
