Fatty acid synthase reprograms the epigenome in uterine leiomyosarcomas
Fatty acid synthase reprograms the epigenome in uterine leiomyosarcomas
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Author / Creator
Guan, Min , Wu, Xiwei , Chu, Peiguo and Chow, Warren A
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
SK-UT-1 uterine leiomyosarcomas (Ut-LMS) cells were transduced with a fatty acid synthase (FASN)-containing retroviral vector to recapitulate the "lipogenic phenotype of cancer." Consistent with this model, forced expression of FASN enhanced SK-UT-1 proliferation, migration, and cellular motion. Further investigation showed FASN promotes trimethyla...
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Full title
Fatty acid synthase reprograms the epigenome in uterine leiomyosarcomas
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Record Identifier
TN_cdi_plos_journals_1914149214
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1914149214
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0179692
