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Autophagy mediates cell cycle response by regulating nucleocytoplasmic transport of PAX6 in limbal s...

Autophagy mediates cell cycle response by regulating nucleocytoplasmic transport of PAX6 in limbal s...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1917696149

Autophagy mediates cell cycle response by regulating nucleocytoplasmic transport of PAX6 in limbal stem cells under ultraviolet-A stress

About this item

Full title

Autophagy mediates cell cycle response by regulating nucleocytoplasmic transport of PAX6 in limbal stem cells under ultraviolet-A stress

Publisher

United States: Public Library of Science

Journal title

PloS one, 2017-07, Vol.12 (7), p.e0180868-e0180868

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

Subjects

Subjects and topics

More information

Scope and Contents

Contents

Limbal stem cells (LSC) account for homeostasis and regeneration of corneal epithelium. Solar ultraviolet A (UVA) is the major source causing oxidative damage in the ocular surface. Autophagy, a lysosomal degradation mechanism, is essential for physiologic function and stress defense of stem cells. PAX6, a master transcription factor governing corn...

Alternative Titles

Full title

Autophagy mediates cell cycle response by regulating nucleocytoplasmic transport of PAX6 in limbal stem cells under ultraviolet-A stress

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1917696149

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1917696149

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0180868

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