Detecting similar binding pockets to enable systems polypharmacology
Detecting similar binding pockets to enable systems polypharmacology
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
In the era of systems biology, multi-target pharmacological strategies hold promise for tackling disease-related networks. In this regard, drug promiscuity may be leveraged to interfere with multiple receptors: the so-called polypharmacology of drugs can be anticipated by analyzing the similarity of binding sites across the proteome. Here, we perfo...
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Full title
Detecting similar binding pockets to enable systems polypharmacology
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TN_cdi_plos_journals_1919505671
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1919505671
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ISSN
1553-7358,1553-734X
E-ISSN
1553-7358
DOI
10.1371/journal.pcbi.1005522
