The quinic acid derivative KZ-41 prevents glucose-induced caspase-3 activation in retinal endothelia...
The quinic acid derivative KZ-41 prevents glucose-induced caspase-3 activation in retinal endothelial cells through an IGF-1 receptor dependent mechanism
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Retinal microaneurysms, an early disease manifestation of diabetic retinopathy, are associated with retinal endothelial cell (REC) death and macular edema. We previously demonstrated that a quinic acid (QA) analog, KZ-41, promoted REC survival by blunting stress-induced p38 MAPK activation. Herein, we sought to expand our understanding of the pro-s...
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Full title
The quinic acid derivative KZ-41 prevents glucose-induced caspase-3 activation in retinal endothelial cells through an IGF-1 receptor dependent mechanism
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TN_cdi_plos_journals_1927791316
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1927791316
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0180808
