iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction...
iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Mutations in PANK2 lead to neurodegeneration with brain iron accumulation. PANK2 has a role in the biosynthesis of coenzyme A (CoA) from dietary vitamin B5, but the neuropathological mechanism and reasons for iron accumulation remain unknown. In this study, atypical patient-derived fibroblasts were reprogrammed into induced pluripotent stem cells (...
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Full title
iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease
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TN_cdi_plos_journals_1934569986
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1934569986
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0184104
